Engineering Innovation in
E-Health
High Performance Computing and Machine Learning support genomic research to create personalized healthcare pathways.
Approach & Solution
Approach
Engineering D.HUB is the technological partner of the new Center for genomic and Big Data analysis in the Valle d’Aosta. Integrated in the regional health system, the Center aims at promoting and accelerating the adoption of Precision Medicine in healthcare, improving diagnosis processes and allowing personalized therapies for patients. It also provides the opportunity to create a research center in the valley capable of attracting high potentials, contribute to its growth and improve regional health.
Engineering D.HUB will provide its experience and innovative technologies, both on infrastructure and data integration & analysis, to create a high-performance computational infrastructure (HPC), a facility for genomic screening and a holistic patient health record. These technologies allow to analyze and correlate an enormous amount of information from different sources, analyzing patient’s genomic profile, together with data related to clinical history and lifestyle habits, defining personalized therapies also through Artificial Intelligence solutions.
Engineering D.HUB will provide its experience and innovative technologies, both on infrastructure and data integration & analysis, to create a high-performance computational infrastructure (HPC), a facility for genomic screening and a holistic patient health record. These technologies allow to analyze and correlate an enormous amount of information from different sources, analyzing patient’s genomic profile, together with data related to clinical history and lifestyle habits, defining personalized therapies also through Artificial Intelligence solutions.
Solution
The project aims to sequence about 5,000 genomes in 5 years on patients suffering from neurodevelopmental, neurodegenerative and oncological diseases.
Although the clinical research carried out throughout the Project is focused on these clinical areas, the medium and long-term goal is to introduce the technological solution and the diagnostic-therapeutic approach developed also to other pathologies.
Engineering D.HUB co-finances the project and provides services, hardware and software platforms and its Data Center. In particular, we will be responsible for the creation and management of the High Performance Computing IT infrastructure, which will have to meet relevant computational and performance needs necessary for laboratory's activities. In addition, we will implement a holistic EHR (Electronic Health Record) solution to make available patients' genetic information both through data already available in their medical records, but also with additional unconventional data related to their lifestyle and well-being, which are useful for the diagnostic activity.
In addition to the medical facilities of the AUSL VdA, Engineering D.HUB collaborates with OAVDA and IIT, scientific partners of the project, supporting computational development groups that, with Machine Learning and Deep learning algorithms, analyze genomic information for the diagnosis of target diseases and the identification of more effective therapeutic pathways. The project has received co-funding by the Investment program for growth and employment of the FESR - European Regional Development Fund 2014/2020 (Autonomous Region of Valle D'Aosta) and the FSE - European Social Fund 2014/2020. For more details see the project website: www.5000genomivda.it
Although the clinical research carried out throughout the Project is focused on these clinical areas, the medium and long-term goal is to introduce the technological solution and the diagnostic-therapeutic approach developed also to other pathologies.
Engineering D.HUB co-finances the project and provides services, hardware and software platforms and its Data Center. In particular, we will be responsible for the creation and management of the High Performance Computing IT infrastructure, which will have to meet relevant computational and performance needs necessary for laboratory's activities. In addition, we will implement a holistic EHR (Electronic Health Record) solution to make available patients' genetic information both through data already available in their medical records, but also with additional unconventional data related to their lifestyle and well-being, which are useful for the diagnostic activity.
In addition to the medical facilities of the AUSL VdA, Engineering D.HUB collaborates with OAVDA and IIT, scientific partners of the project, supporting computational development groups that, with Machine Learning and Deep learning algorithms, analyze genomic information for the diagnosis of target diseases and the identification of more effective therapeutic pathways. The project has received co-funding by the Investment program for growth and employment of the FESR - European Regional Development Fund 2014/2020 (Autonomous Region of Valle D'Aosta) and the FSE - European Social Fund 2014/2020. For more details see the project website: www.5000genomivda.it
Results
Personalized treatment pathways
New precision diagnostic methodologies
Patients’ DNA mapping
New methodologies to analyze genomic information
Support for medical diagnostics
Project value
Innovation
Process performance
Enabling Technologies
AI & Advanced Analytics
Cloud
Project Team
Engineering D.HUB